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It does not mean the compound "stopped working." It means it is clearing your system as intended

People with pernicious anemia or other medical conditions affecting B12 levels

However, it has also been shown to reduce body fat in healthy individuals

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349,350 This change suggests that liraglutide not only inhibits inflammation and cartilage degradation but may also promote the synthesis and accumulation of cartilage matrix, thereby helping to protect and repair joint cartilage

Lesch KP, Widerlv E, Ekman R, Laux G, Schulte HM, Pfller H, Beckmann H