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Another group was synthetically developed by replicating the structure of a naturally occurring protein isolated from saliva of the gila monster, exendin-4 (Ex-4), with substantial homology to native GLP-1

Glucose is taken up through the insulin-independent glucose transporter GLUT2 ( SLC2A2 , rodents) or GLUT1 and GLUT3 ( SLC2A1 and SLC2A3 , humans), phosphorylated by glucokinase and metabolised to produce ATP

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However, the fundamental principle remains: a larger GH pulse will have a larger (though still transient) effect on blood glucose

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