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It can indicate serious oral or medical conditions if untreated.

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One potential issue associated with high doses of folic acid is that it has a masking effect on the diagnosis of pernicious anaemia due to vitamin B 12 deficiency, and may even precipitate or exacerbate neuropathy in vitamin B12-deficient individuals

Cancers 8(10):90 Cowen EW, Nguyen JC, Miller DD, McShane D, Arron ST, Prose NS et al (2010) Chronic phototoxicity and aggressive squamous cell carcinoma of the skin in children and adults during treatment with voriconazole

Abstract The incidence of prostate cancer is the second most among male cancers after lung cancer