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There is no ramp-up phase and no dose escalation

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History [edit] Descriptions of deficiency effects [edit] Between 1849 and 1887, Thomas Addison described a case of pernicious anemia, William Osler and William Gardner first described a case of neuropathy, Hayem described large red cells in the peripheral blood in this condition, which he called "giant blood corpuscles" (now called macrocytes), Paul Ehrlich identified megaloblasts in the bone marrow, and Ludwig Lichtheim described a case of myelopathy

Key areas of research: NNMT Research Metabolic Research Body Composition Research Adipose Tissue Research Energy Expenditure Research Cellular Metabolism Research Glucose Regulation Research Obesity Research Methylation Pathway Research Cellular Energy Research References NNMT Regulates Cellular Metabolism: A Potential Therapeutic Target Discovery of 5-Amino-1MQ as a Potent NNMT Inhibitor The Role of NNMT in Obesity and Metabolic Regulation References are provided for research context only and do not constitute medical claims

Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity (Nature, 2014) Synonyms: 5-amino-1-methylquinolinium, SCHEMBL6403148, SCHEMBL9331979, CHEMBL4116828, ZMJBCEIHNOWCMC, UHFFFAOYSA-O