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Gene expression Mouse whole pancreas and epithelial scrapes from duodenum and ileum were immediately homogenised in Trizol (Thermo Fisher Scientific, Waltham, MA, USA) using a Tissuelyser II (Qiagen, Hilden, Germany)

At the same time, in our previous study on the protective effect of Ebselen on renal ischemia-reperfusion injury, we found that the expression level of GPX3 in renal tissues decreased after renal IRI, and when the level of GPX3 increased after the use of Ebselen, the pathological damage of renal histologic damage was alleviated, and we speculated that GPX3 may play an important role in the oxidative stress response of renal ischemia-reperfusion injury (Wu et al., 2022)

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The additional GIP action affects insulin sensitivity and energy utilization, which can lead to greater weight-loss potential for some patients

Velocity Pharmaceutical Development (2018)