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Mechanistically, the common thread appears to be dampening drug-evoked dopamine signaling in the nucleus accumbens and engaging GLP-1 anti-craving circuits involving the VTA, nucleus accumbens, lateral septum, laterodorsal tegmentum, and nucleus tractus solitarius
Kohan (18:31) Mm-hmm
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Meanwhile, they also affect the brain, decreasing appetite centrally
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