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We need several large-scale trials to assess safety, particularly in young and middle-aged women, [who] constitute the majority of the population with migraine. The Managing migraine nowadays has been very advanced, and it depends on the cause and frequency of the migraine, said Mikhael

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Fourth, MR requires stringent assumptions, i.e., the genetic variants are associated with the exposure, no confounders of the associations of the genetic variants with the outcomes exist, and the genetic variants are not associated with the outcomes other than via affecting the relevant exposure (no pleiotropy) [17]

Propensity score matching and covariates Patients in the GLP-1 agonists group were matched to a patient in the non-GLP-1 agonists group using 1:1 propensity score matching (PSM) to reduce confounders 22

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