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The frequency for microdosing is still daily in most protocols

In the late 1970s, it was first shown that an APAP overdose triggered massive LPO in the liver, measured by ethane and pentane exhalation, and severe liver injury with high mortality in a murine model [11]

doi: 10.1111/j.1600-079x.1999.tb00582.x

This variation reflects individual receptor sensitivity and metabolic differences

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