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NICE recommends semaglutide for weight management only within specialist weight management services and under more restricted BMI criteria than the MHRA licence

Researchers are investigating the combined activity of GLP-1, GIP and glucagon pathways in relation to: Appetite-related signalling Energy balance Energy expenditure Glucose metabolism Substrate and fat metabolism Body-weight regulation Weight-management research models The triple-receptor profile provides researchers with a model for investigating how multiple metabolic signalling pathways may interact within controlled experimental environments

Tirzepatide is a synthetic dual glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 receptor agonist

Source:The Lancet Background What retatrutide is Retatrutide, also known by its development code LY3437943, is an investigational once-weekly injectable being developed by Eli Lilly and Company