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Notably, GGCT overexpression paradoxically enhanced the metabolic flux from Gln to GSH m + 5 (Fig

Proteins were then transferred into a nitrocellulose membrane with a pore size of 0.22 M (Amersham, GE Healthcare)

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Cell subpopulations with high OXPHOS activity consistently exhibit greater drug resistance, suggesting that mitochondrial metabolic heterogeneity may serve as a critical biomarker for resistance stratification and therapeutic classification [66]

Children with Down syndrome have abnormal metabolic profiles and show increased incidence of a large number of serious diseases including leukemia and diabetes [61]