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There is a meaningful difference between mechanistic plausibility and clinical evidence in humans

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Semaglutide produced less weight loss than tirzepatide head-to-head, about 14% versus 20%. Its body-composition substudy measured a roughly 62:38 fat-to-lean loss split by mass, compared with about 75:25 for tirzepatide in a separate trial. The scan overstates muscle loss because lean mass includes water and organ tissue

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Joint and Bone Health Some research has looked at cartilage and bone healing in animal models of joint injury