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Glucagon-like peptide-1 (GLP-1) is an intestinal hormone that regulates blood sugar, suppresses hunger, and slows gastric emptyingyet most adults produce insufficient amounts due to processed food consumption and lack of physical activity
When Rybelsus is used with insulin or sulfonylureas, the doses of these medications may need to be reduced to prevent hypoglycaemia
A 2022 study in Obesity found that adding resistance exercise to GLP-1 therapy significantly improved lean mass preservation and metabolic markers compared to medication alone
Weight loss may begin after several weeks and continues gradually
However, it may also be that at constant, high levels of estradiol (as in anovulatory cycles, or in hormonal preparations), its anorexic effects are blunted