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10.1172/jci.insight.90777 JCI Insight 55 LiddellJ
cultured insulin-sensitive human HepG2 cells under high-glucose conditions and administered cocoa-derived polyphenols and epicatechin, which blocked tyrosine phosphorylation and lowered total IR, IRS-1, and IRS-2 levels through PI3K/AKT and AMPK pathway inhibition, thereby mitigating high-glucose-induced insulin signaling impairment that alters gluconeogenesis (Isabel et al., 2014)
Low levels of glutathione have been linked to impaired immunity, increased inflammation, and accelerated aging
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Chapter 14 Red Blood Cell and Bleeding Disorders
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