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Pure-tone thresholds and speech recognition significantly improved after treatment, and no serious side effects were observed

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The dose-finding phase 2 trial randomised 706 adults with obesity, or overweight plus at least one weight-related comorbidity, to once-weekly cagrilintide at 0.3, 0.6, 1.2, 2.4 or 4.5 mg, weekly placebo, or daily liraglutide 3.0 mg as an active comparator, all alongside lifestyle intervention

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A subcutaneous (SC) injection takes a slightly different approach

In experiments using melatonin, either melatonin (10mg/kg, Sigma) or an equivalent volume of DMSO (Sigma) was intraperitoneally injected each day for three days at 17:00, immediately after intranasal challenges had been performed