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Another common point of confusion is the half-life slump

IV delivery places the administered dose into systemic circulation, but that does not mean 100% enters target cells, remains intact, reaches a specific organ, or produces a clinical benefit

10.1177/1073274821999655 15 BourassaM

Patients treated with long-term antiretroviral therapy usually develop, among other concerns, lipodystrophy, insulin resistance, and increased cardiovascular risk