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Semaglutide on the other hand displays limited efficacy in crossing the BBB, but despite this fact it was proven to access the brainstem, septal nucleus and hypothalamus [42]
It is also important to remember that ROS may inactivate histone deacetylase-2, an essential factor for corticosteroid inhibition of the inflammatory response [115]
The anti-inflammatory mechanisms appear to be independent of weight loss or glycemic improvement, suggesting direct immunomodulatory properties
As adjunct therapy, GLP-1 RAs could serve alongside standard HS treatments such as antibiotics and biologics
Hart et al
Lonnemann N, Hosseini S, Marchetti C, Skouras DB, Stefanoni D, DAlessandro A, et al
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