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The combination produced the greatest weight loss during treatment and, despite some regain after discontinuation, remained most effective in followup
This suggests that the indication and reason for taking GLP-1s likely play a role in effectiveness, as those focused on only glycemic control may not see any change in weight loss, and vice versa
Moreover, liraglutide trials in patients with HFrEF provided no clinical benefit, underscoring that the efficacy of incretin receptor agonism does not uniformly extend across heart-failure phenotypes and that remodelling mechanisms may differ by disease context [47]
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La hiperglucemia crnica condiciona un microambiente entrico alterado, con incremento del estrs oxidativo, formacin de productos finales de la glucosilacin avanzada, inflamacin y reduccin de neurotransmisores y hormonas locales, afectando la vasculatura entrica y la celularidad del msculo liso19
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