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A double-blind study in chronic insomniac patients did not produce a clean confirmation of benefit (PMID 1299794), and other human work has treated the endogenous compound as a marker rather than a confirmed sleep agent

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Exposure of RAW 264.7 cells to LPS for four hours dramatically increased the secretion of IL-6 to 613.2 35.1 pg/ml and TNF- to 1556.3 23.3 pg/ml