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Genetic variation in GLP-1 receptor expression predicts gastrointestinal side effects of semaglutide

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Patients receiving sitagliptin with metformin and glimepiride had significant improvements in A1C and FPG compared to patients receiving placebo with metformin and glimepiride (Table 5), with mean reductions from baseline relative to placebo in A1C of -0.9% and in FPG of -21 mg/dL