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Depression Depression shows the strongest preclinical foundation

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For the neurotoxic profile, reducing GABA synthesis inhibition or preventing the transformation into the toxic state through microglia modulation have demonstrated improvements in cognitive outcomes 58,134

DET1 serves as a bridge between COP1 and Ube2e family members Since Ube2e2 is positioned in close proximity to both DET1 and COP1, we investigated whether DET1 or COP1 interact with Ube2e family members by co-transfection and in vitro pull-down experiments

Altered signaling pathways At the systems level, diverse oncogenic signaling pathways intersect to drive common downstream programs that sustain tumor survival, plasticity, metabolic fitness, DNA repair capacity, and immune suppression, forming the mechanistic basis of therapeutic resistance (Fig