In addition to being the natural incretin hormone that regulates blood sugar, GLP-1 is also a recognized neurotransmitter whose receptors are expressed in many regions of the brain
The gastric emptying delay at 1.0mg is substantially greater than at 0.5mg
The risk of pancreatitis with GLP-1 agonist medications is well-documented, though the incidence remains very low (0.27% to 2.2%, depending on the study)
Elevated CRP levels are independently associated with increased cardiovascular risk
As the evidence base for retatrutide continues to develop, guidance from bodies such as NICE and the MHRA will evolve accordingly, and your clinical team will be able to keep you informed of any changes in availability or recommendations
McGehee, D.S., Heath, M.J., Gelber, S., Devay, P