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It's also important to understand that supplementation tends to be most noticeable in individuals who are more active, training consistently, or operating in a calorie deficit

Chen A et al

doi:10.1016/j.nic.2004.02.002

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J Neurochem 105:11441152 Grange E, Gharib A, Lepetit P, Guillaud J, Sarda N, Bobillier P (1992) Brain protein synthesis in the conscious rat using l-[ 35 S]methionine: relationship of methionine specific activity between plasma and precursor compartment and evaluation of methionine metabolic pathways

Astrocytes, specialized glial cells in the brain, play a crucial role in maintaining cholesterol homeostasis, which becomes disrupted in HD