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In NAFLD mice, liraglutide could improve the hypoadiponectinemia-induced inflammatory stress by inhibiting the MKK4/JNK signaling pathway, inhibit liver adipogenesis by activating AMPK, and induce autophagy through the AMPK/mTOR pathway, hence improving the levels of liver lipids (198)
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5 ml of each solution was added to a beaker containing 20 ml acidified (pH 4.0) water under constant stirring at 900 rpm to prepare five different drug-loaded zein nanoparticle dispersions
Lipovac M, Bodner F, Imhof M, Chedraui P
A post hoc subgroup analysis assessing changes in BMI standard-deviation scores between participants with one or more gastrointestinal adverse events and those with none revealed that the effect of liraglutide in reducing BMI standard-deviation scores was independent of gastrointestinal adverse events (P = 0.82) (245)
Our BETP-sensitized cAMP screening assay (SA +BETP) was adapted to a single-point format and employed in an HTS of 2.8 million compounds from the Pfizer compound collection
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