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& Buttgereit, F
329,330 In degenerative joint diseases like OA, the metabolic balance of chondrocytes is disrupted, leading to the overproduction of degrading enzymes and inflammatory mediators, including iNOS, MMP-13, and ADAMTS5 (a disintegrin and metalloproteinase with thrombospondin motifs 5), which participate in cartilage degradation and inflammatory processes
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This has been reported in patients undergoing elective surgeries or procedures while taking GLP-1 medications
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doi:10.1146/annurev-clinpsy-032813-153705
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