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This is especially important for people with type 2 diabetes, who may not produce enough insulin on their own

However, it is not proven if this actually leads to better results in humans

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Given that the glucose-lowering effect of metformin is so strong and is independent of incretin signalling, it might be difficult to detect the beneficial effect of metformin on the incretin axis in human studies

At each timepoint, a small proportion of nonusers who remained under observation were found to change and become current users in both SGLT2i and GLP-1 RA cohorts

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