Less water means a stronger mix and smaller injections
Talk to a doctor about whether your Ozempic dose needs adjustment or if an alternative GLP-1 might work better for you
however, these benefits were limited only to obese patients (99)
Prog Clin Biol Res 321:383402 Ruzicka L, Bradford YM, Frazer K, Howe DG, Paddock H, Ramachandran S, Singer A, Toro S, Van Slyke CE, Eagle AE, Fashena D, Kalita P, Knight J, Mani P, Martin R, Moxon SAT, Pich C, Schaper K, Shao X, Westerfield M (2015) Zfin, the zebrafish model organism database: Updates and new directions
More serious considerations include risk of pancreatitis, gallbladder problems, kidney injury (often related to dehydration from gastrointestinal symptoms), and rare cases of medullary thyroid cancer (these medications carry a black box warning for patients with personal or family history of MTC or MEN2 syndrome)
The 2-OH-E1 route catalyzed by CYP1A1 is a stable route, and it can be easily metabolized further through methylation, which is accomplished by catechol-O-methyltransferase (COMT)