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Anti-CD274 (PD-L1) immunotherapy triggers IFN- release from CD8 + T cells, which suppresses SLC7A11 and induces ferroptosis, thereby enhancing immunotherapy efficacy [88]
The gut and immune system also depend on microbes
The researchers found that randomization to GLP-1 RA treatment among all included trials was associated with increased risks for gallbladder or biliary diseases (pooled relative risk [RR], 1.37), specifically cholelithiasis, cholecystitis, and biliary disease (RRs, 1.27, 1.36, and 1.55, respectively)
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