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174 Currently, Eli Lilly has initiated a Phase III development program to further investigate the efficacy and safety of orforglipron in treating obesity, overweight, and T2DM

those with less efficient pathways may benefit from dose adjustment or extended timelines discussed with their provider

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However, given the novelty of this therapeutic approach, the available evidence may be influenced by publication bias and early optimism, and long-term mechanistic and clinical outcome data remain limited