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In our study, FOXO4-DRI was found to effectively promote apoptosis in senescent cells by blocking the FOXO4-P53 interaction and facilitating P53 phosphorylation

mSystems 6 , e0104521 (2021)

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Nat Rev Endocrinol 15(11):635650 Khin PP, Lee JH, Jun H-S (2023) Pancreatic beta-cell dysfunction in Type 2 diabetes

found that histidine catabolism affects the sensitivity of cells to methotrexate, and dietary supplementation of histidine maintains a suitable chemotherapy effect with a low dose of medication

N., & Stefanadis, C