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96 Of note, GTPSCS functions as a lactyl-CoA synthetase in the nucleus and interacts with p300 to form a histone lactyltransferase complex to synergistically modulate H3K18la in this process

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Results Impaired epithelial GPX4 activity features CD To investigate a role of reduced GPX4 activity and LPO in human IBD, we analyzed biopsy-derived IEC-enriched specimens from the lesional and non-lesional mucosa of CD and ulcerative colitis (UC) patients with active disease

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