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An unhealthy gut can lead to inflammation and allow toxins to enter the bloodstream, both of which contribute to insulin resistance

The reviewed studies also noted increased production of decorin, a proteoglycan that plays a role in collagen formation and wound healing

FAT10, a ubiquitin-independent signal for proteasomal degradation

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Nucleotide-binding oligomerization domain-containing protein 2 (Nod2) is a cytosolic PRR involved in innate immune inflammatory response during infection by viruses and bacteria and its hallmark function is to activate the NFB signaling pathway, which promotes expression and production of a proinflammatory cytokine network 14,15,16,17,18,19,20,21