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Eng who had strong expertise in RIA for measuring peptides in blood and new methods to isolate peptides and unravel their structures
In our study, NAC co-treatment not only ameliorated the impaired performance in NOR, Y maze, and MWM in chronic ethanol-exposed APP/PS1 mice, but also significantly alleviated the neuroinflammation, downregulated TNF- protein level and restored SYP, PSD95 and BDNF protein levels in the hippocampus of ethanol-exposed APP/PS1 mice, further suggesting the critical role of chronic ethanol exposure mediated oxidative stress and neuroinflammatory damage in AD pathology and the cognitive behavioral impairments
Not just in quantity, but in quality and conclusiveness
For example, PACs upregulate the expression of GSH, GPX4, SLC7A11, Nrf2, and HO-1 and downregulate the expression of TFR1, ACSL4 and regulate SCI, thereby promoting ferroptosis-mediated functional recovery in SCI mice (Zhou et al., 2020)
3.1.3 Platinum-based compounds Platinum-based compounds represent a crucial category of anticancer drugs extensively utilized in the treatment of solid tumors [70]
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