The main concern is stacked GI side effects - both compounds slow digestion through different pathways, so combining them can amplify nausea, vomiting, and constipation
This is the crux of the contested, under-replicated characterization: the problem is not that the data are fabricated or absent, but that they are concentrated, mostly preclinical, and insufficiently reproduced by outsiders
Others might see only modest results with Zepbound
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Risk of Gastrointestinal Cancers among Patients with Appendectomy: A Large-Scale Swedish Register-Based Cohort Study during 1970-2009