In addition, metformin should be promptly withheld in the presence of any condition associated with hypoxemia, dehydration, or sepsis
This practice increases infection risk, may cause needle damage, and can result in incomplete medication delivery
Robson, M
Second, improvements in IR and glycaemic indices are most apparent in higher-burden phenotypes, particularly in women with impaired glucose tolerance/prediabetes or related metabolic comorbidities, where changes in HOMA-IR, fasting glucose and OGTT profiles are more pronounced and may plausibly reduce periconception metabolic risk
IGF-1 has been implicated in the development of acne vulgaris by stimulating sebum production. The authors noted the study had limitations, including the fact that it only looked at formally diagnosed acne, which might miss milder cases
L., Moller, D