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As a result, this mechanism is unlikely to apply universally
J Neurosci 25(38):88078814
Predictors of persistent post-surgical pain following total knee arthroplasty: a systematic review and meta-analysis of observational studies
Excessive amounts do not deliver better results
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Its primary biological functions center on tissue remodeling: it stimulates collagen synthesis (types I and III), promotes decorin production, increases glycosaminoglycan synthesis, and activates metalloproteinase pathways for controlled tissue remodeling
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