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Semaglutide in renal ischemia-reperfusion injury in mice [PMID: 36937464] Laboratory literature summary: Semaglutide in renal ischemia-reperfusion injury in mice
Nutr Rev (2020) 78(10):82740
This was seen in association with increased baseline and post-prandial intact GLP-1 concentrations, reduced post-prandial glucagon levels and sustained insulin levels, which in the presence of lower glucose levels resulted in an increase of insulinogenic index as a sign of stimulated beta-cell function, which provided a first insight into the mechanism of action of DPP-4 inhibition in type 2 diabetes (Figure 4)
PMID: 41964043 Lian J et al
Their protective mechanisms combine barrier function, pH responsiveness and mucoadhesion: chitosan dissolves and becomes bioadhesive in acidic media, protecting payloads in the stomach and promoting intestinal release [114]
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