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Acknowledgements This study was supported by the Ministre de la Recherche et de la Technologie, Inserm and Universit Clermont-Auvergne (UMR1071 - Units Mixtes de Recherche), INRAE (Institut national de la recherche agronomique, USC-1382) and by grants from the Conseil Rgional dAuvergne, CPER (Contrats de Plan tat-Rgion) EPICURE 2016, FRM (Fondation pour la Recherche Mdicale), la Ligue Contre le Cancer 03/15/63/71 and by the French government IDEX-ISITE initiative (Grant number: 16-IDEX-0001-CAP 20-25) of the University of Clermont Auvergne

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