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The mechanism seems to be independent of the catalytic activity, since these effects were not mimicked by systemic DPP-4 inhibition (73, 82), and it was suggested that soluble DPP-4 interacted with caveolin-1 on adipose tissue macrophages, the down-stream effects of which combined with actions of other pro-inflammatory molecules such as factor Xa, to lead to activation of the inflammatory signaling pathway (83) (Figure 3)
Dardevet D, Sornet C, Balage M, Grizard J
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Research suggests that acne-prone skin tends to be deficient in linoleic acid in sebum
Vitamin D correction with high-dose supplementation (50,000 IU weekly for eight to twelve weeks, then maintenance dosing) can normalize levels within three months
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