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PE-22-28's in vivo studies have used intraperitoneal injection

In the larger SELECT trial in 2023, patients with heart failure, atherosclerotic disease, and overweight or obesity, treated with semaglutide 2.4 mg showed reduction in major adverse cardiac events (MACE) and heart failure end points regardless of heart failure subgroup being HFrEF or HFpEF [56,57,58]

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Chi-square tests were conducted for categorical variables, while the KruskalWallis test was used for non-normally distributed continuous variables to compare median values across different nicotine craving categories (increased, reduced, and no change)

High-risk patients should be prescribed glucagon emergency kits and receive training in their use, with similar training provided to household members