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The first step in the synthesis of GSH is the formation of -glutamyl-cysteine (GluCys) from the constituent amino acids glutamate and cysteine by the enzyme -glutamyl-cysteine synthetase (GCS, also called glutamate cysteine ligase (GCL))

High baseline oxidative stress or chronic inflammation may theoretically justify antioxidant support, but this remains individualized and requires provider interpretation

Renal failure and/or hepatic failure : Follow phenobarbital levels and re-dose accordingly

Stress hormone levels improved, as did the participants ability to manage the stress