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Back Lau, J, Bloch, K, Schffer, L, et al (24 Sept 2015) 'Discovery of the once-weekly glucagon-like peptide-1 (glp-1) analogue Semaglutide', Journal Medicinal Chemistry , 58/18

Its still in clinical trials

244 Chlorogenic acid was also shown, in a mouse model, to decrease plasma levels of total and LDL cholesterol and promote cholesterol efflux from macrophages, a process that helps prevent the buildup of atherosclerotic plaque

Compared with controls, GLP-1 agonist therapy reduced HbA1c by -0.30% with a larger effect in children with (pre-)diabetes (-0.72%) than in children with obesity (-0.08%)

Peptide approaches aim for slower, self-regulated change

Levels of GHK-Cu decline significantly with age dropping from approximately 200 ng/mL in young adults to near undetectable levels by age 60