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In a 2025 review, after 1,200 mg intravenously twice a week for six weeks, 37.5% of participants reported lighter skin compared with 18.7% in the placebo group, and the effect faded after about six months

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Previous FDA panels on the topic have been composed of academics and researchers

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doi: 10.3969/j.issn.1000-4718.2014.06.026 149 Daz-GonzlezFAltenRHBensenWGBrownJPSibleyJTDougadosMet al