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GLP-1R binds to ligands to internalize GLP-1R, and can independently reduce TG accumulation in hepatocytes by activating key signaling molecules downstream of insulin receptor substrate 2 (IRS2)

Some well-known GLP-1 drugs include semaglutide (marketed as Ozempic and Wegovy) and liraglutide (Saxenda and Victoza)

54, 10631075.10.1111/j.1365-313X.2008.03477.x 17 HellR.BergmannL

The homogenized tissue was transferred to 5 mL tubes containing 1 mL of 1 M NaOH and incubated at 80 C for 15 min

It modulates the ratio of acetyl-CoA to CoA in the mitochondria, which affects pyruvate dehydrogenase activity and glucose oxidation

The trade-off is cost and availability