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Because GH and IGF-1 promote protein synthesis and lipolysis, these hormonal changes provide a plausible mechanistic basis for modest increases in lean body mass, improved recovery and support for fat loss seen in clinical and observational contexts, but robust controlled trials explicitly measuring those endpoints are still lacking

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A prominent example of this phenomenon is the Warburg effect, which describes how tumor cells preferentially utilize glucose for glycolysis even in the presence of sufficient oxygen, thereby supporting their rapid proliferation (110)

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