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Furthermore, this traditional, nutrient-induced, neural, and hormonal gutbrain signaling pathway fails to incorporate the role of the gut microbiome in mediating gut-derived feedback mechanisms

[21] Patients with a history of pancreatitis, severe gastrointestinal conditions, or significant renal impairment would require careful individual clinical assessment before any future prescribing consideration, in line with the relevant UK SmPCs

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This work has been done within the efforts of the European Reference Network EpiCARE ( Conflict of interest The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest