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This work was supported by the Voelcker Fund Young Investigator Award to L.C., NIA R01AG070214 to L.C., NIA R01AG071591 to L.C., CPRIT RR160017 to Z.L., V Foundation V2016-017 to Z.L., V Foundation DVP2019-018 to Z.L., Voelcker Fund Young Investigator Award to Z.L., UT Rising STARs Award to Z.L., Susan G