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Mice were fed either chow (Altromin #1324, energy density 2.85 kcal/g, Brogaarden, Lynge, Denmark) or a high-fat diet (60% kcal fat, #D12492, energy density 5.21 kcal/g, Ssniff, Soest, Germany) for 35 weeks prior to drug treatment

Process differences introduced by follow-on manufacturers may result in changes in quality and clinical outcomes

Zepbound can cause nausea, especially during titration

Industry researchers estimate that while about 12% of United States citizens have used a GLP-1 medication for weight loss, 54% of adults who have taken GLP-1s say it was difficult to afford, and 53% say it was still too expensive even if they received insurance coverage for the medication

And so Im finding

By 2015, the received wisdom across large-pharma endocrinology was that GCGR antagonism was pharmacologically interesting but pharmacokinetically and pharmacodynamically incompatible with chronic administration