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These molecules activate two metabolic hormone receptors at once, most commonly: GLP-1 + GIP GLP-1 + glucagon Dual-agonist peptides demonstrated how combining hormone pathways might produce broader metabolic signaling compared to single-pathway compounds

But whats unique about GLP-1 use is that these drugs can potentially simulate rapid weight loss, which could worsen muscle loss compared to more gradual weight loss, Pinto says

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