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In late 2023, tirzepatide (Mounjaro) surpassed dulaglutide (Trulicity) as the second most commonly prescribed ADM

Quick Answer: Most patients see blood glucose improvements within 14 weeks of starting GLP-1 therapy, while noticeable weight loss typically becomes apparent after 46 weeks, with peak effects at 6072 weeks

So what do we know from the anecdata

Liu X, Zhang Z, Song Y, et al

While the thigh is a common area for intramuscular injections, you can also inject subcutaneously if you have enough fat there

The TRANSCEND-T2D-1 trial (NCT06354660) demonstrated HbA1c reductions of 1.7-2.0% and 36.6 lbs mean weight loss in type 2 diabetes participants over 40 weeks