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No documented interactions contraindicate combined use, and the distinct pathways suggest potential synergy
150(7):33083317 Manna PR, Soh J-W, Stocco DM (2011) The involvement of specific PKC isoenzymes in phorbol ester-mediated regulation of steroidogenic acute regulatory protein expression and steroid synthesis in mouse Leydig cells
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Discontinuation, however, may result in a gradual return to the natural skin tone
Spontaneous reports cannot prove causation or incidence